Is Hidradenitis Suppurativa Genetic? Causes and Risk Factors
Hidradenitis suppurativa (HS) is a chronic skin condition that forms painful nodules and abscesses under the skin. This condition causes inflammation and the formation of fistulas on the surface of the skin. But is hidradenitis suppurativa a genetic disease? In this article, we will examine whether the disease is genetic and the risk factors.
Hidradenitis Suppurativa
Is Hidradenitis Suppurativa Genetic?
Hidradenitis Suppurativamay be associated with a genetic predisposition. Research shows that the disease can be influenced by genetic factors and that people with a family history of the disease have a higher risk. However, this factor alone is not enough to say that hidradenitis suppurativa is genetic; environmental factors and lifestyle also play a big role.
Family Background and Genetic Predisposition
Approximately 30% of individuals with hidradenitis suppurativa have a family member with the same disease. This indicates that the disease may be associated with a genetic predisposition. People with a family history of the disease may be at higher risk of developing hidradenitis suppurativa.
Genetic Mutations
Some research suggests that hidradenitis suppurativa may be linked to genetic mutations. Mutations in genes such as NCSTN, PSEN1, and PSENEN may play a role in the development of the disease. These genes are important for the normal functioning of skin cells and the immune system.
Non-Genetic Risk Factors of Hidradenitis Suppurativa
Apart from genetic predisposition, the disease has many other risk factors. These factors can increase the possibility of the disease occurring and worsen symptoms.
Smoking
Smoking is one of the most common triggers of hidradenitis suppurativa. Smoking can exacerbate the disease by increasing skin inflammation. Smoking can also negatively affect the response to treatment.
Obesity
Obesity is a major risk factor in the development of hidradenitis suppurativa. Excess weight can cause friction and irritation of the skin, which increases the risk of inflammation. Weight control can play a critical role in managing the disease.
What should be done in case of genetic predisposition?
People with a family history of hidradenitis suppurativa should be more alert to symptoms. Early diagnosis is crucial to slow the progression of the disease and evaluate treatment options. Regular dermatologist check-ups are recommended for individuals with a genetic predisposition.
Early Diagnosis and Treatment Options
Early detection is critical to prevent disease progression and minimize damage to the skin. At Avrupa Cerrahi Proctology Center, we offer modern methods and personalized treatment plans for the treatment of hidradenitis suppurativa. If you have a genetic predisposition, contact our specialists for early diagnosis and treatment options.
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